IL-1β knockout increases the intestinal abundancy of Akkermansia muciniphila

Abstract The proinflammatory cytokine interleukin-1β (IL-1β) is known to be upregulated in patients suffering from metabolic syndrome. IL-1β contributes insulin resistance obesity and type 2 diabetes, yet its influence on the intestinal microbiome incompletely understood. data presented here demonstrate that mice genetically deficient show a specific alteration of colonisation small group bacteria. Especially Akkermansia muciniphila , bacterium reported inversely associated with obesity, cardiometabolic diseases low-grade inflammation, showed increased knockout mice. In comparative microarray analysis mucus scrapings colon mucosa wildtype mice, angiogenin 4 mRNA was strongly reduced animals. Since presence culture medium significant growth inhibition A. which not detectable for other bacteria tested, induced expression strong candidate responsible suppression colonisation. Thus, indicate might lacking link between inflammation abundance as observed variety chronic inflammatory disorders.